Dataset included from Journal of Alzheimer's disease publication "Accumulation of pTau231 at postsynaptic density in Alzheimer's Disease. This includes validation of synaptosomal fraction richness in Figure 5, tTau and pTau231 Simoa Quanterix synaptosomal fraction data for Supplementary figure 2, entorhinal cortex PSD95 P4 adjusted total tau and pTau231 values from Simoa Quanterix for generation of model shown in figure 4, quantitative AMPA immunohistochemical staining data used for generating figure 2, NanoString protein panel data used to generate heatmap in figure 7, quantitative immunofluorescence staining data for pTau214 and PSD95 colocalization studies in figure 3, Braak stage 2 case NanoString protein data for intra-case regional comparisons of disease progression, and synaptosome Simoa total tau and pTau231 data in addition to western blot P4 PSD95 data that was used for generation of figures 4 and 6.