Helicobacter pylori is a highly motile bacteria with numerous unipolar flagella that generates urease. H. pylori's virulence components consist of its flagella and urease. H. pylori frequently causes a chronic infection in the stomach, which can result in gastric and duodenal ulcers, gastric malignancies, and gastric lymphomas, as well as other gastrointestinal illnesses. For H. pylori, there are numerous invasive and noninvasive clinical laboratory testing. Laboratory testing is not recommended for asymptomatic patients and should only be considered if H. pylori infection therapy is planned. If an endoscopy is done on the patient, invasive testing for H. pylori, including as tissue histology, culture, and fast urease assays, are utilized. Patients whose symptoms do not require endoscopy are advised to undergo noninvasive tests for H. pylori, such as enzyme antibody and urea breath tests. Therefore, comprehensive search through literature using electronic databases; PubMed and Embase to search all relevant studies to our review topics, that were published in English language and limited to human subjects up to June 2022.