Diabetes is a prevalent systemic disease affecting a vast proportion of the population worldwide. The effects of diabetes are devastating and well-documented. There is increasing evidence that chronic diseases, the increased production and/or ineffective scavenging of reactive oxygen species (ROS) may play a critical role. The high reactivity of Reactive Oxygen Species determines chemical changes in virtually all cellular components, leading to lipid peroxidation. Production of reactive oxygen species and disturbed capacity of antioxidant defence in diabetic subjects have been reported. It has been suggested that enhanced production of free radicals and oxidative stress is central to the development of diabetic complications. This suggestion has been supported by the demonstration of increased levels of indicators of oxidative stress in diabetic individuals suffering from complications. There are many reports on the effects of antioxidants in the management of diabetes. In this paper, after completing the biography and criticizing all relevant articles, the relationships between diabetes and oxidative stress and the use of antioxidants in the management of diabetes and its complications have been well reviewed. This review will indicate that antioxidants are involved in the pathogenesis of diabetes and its complications. The use of antioxidants reduces oxidative stress and alleviates diabetic complications. Key words : Diabetes, endogenous oxidant, oxidative stress, ROS, etc