Patients may refuse medication for a variety of reasons, including religious views, dietary restrictions, misunderstandings, cognitive impairment, self-harming intent, and simple inconvenience. This decision provides a unique circumstance for pharmacists and staff members of long-term care facilities, particularly if patients have dementia. Therefore, we conducted this review through searching the relevant studies that were published in the electronic databases such as Medline and Embase, with English language up to 2022.Patients may refuse medication for a variety of reasons, including religious views, dietary restrictions, misunderstandings, cognitive impairment, self-harming intent, and simple inconvenience. This decision provides a unique circumstance for pharmacists and staff members of long-term care facilities, particularly if patients have dementia. Therefore, we conducted this review through searching the relevant studies that were published in the electronic databases such as Medline and Embase, with English language up to 2022.