RDM for RTG 2413 Slides will be made available in February 2023. "Aging and cognitive decline are highly correlated in the elderly population even in the absence of neurodegenerative diseases. Despite the high burden for each individual and the society as a whole the molecular, cellular, and behavioral underpinnings of cognitive decline are barely understood. We concentrate on synaptic dysbalances involving (i) altered synaptic proteostasis and (ii) altered functionality of the multipartite synapse accompanied by (iii) dysfunctions of the immune system and (iv) changes in neuromodulation as the core for cognitive decline. SynAGE will address these four transversal themes in a joint effort by a team of molecular/cellular and systems neurobiologists to eventually break ground for innovative intervention strategies." DFG - GEPRIS - GRK 2413: The ageing synapse - molecular, cellular and behavioral underpinnings of cognitive decline (Zugriff am 03.01.2023) DFG Programme: Research Training Groups RDM & GRK 2413: The ageing synapse - molecular, cellular and behavioral underpinnings of cognitive decline Subject Area: Neurosciences Applicant Institution: Otto-von-Guericke-Universität Magdeburg Participating Institution: Leibniz-Institut für Neurobiologie (LIN); Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Standort Magdeburg Participating Researchers: Professor Alexander Dityatev, Ph.D.; Professorin Dr. Ildikò Rita Dunay; Professor Dr. Emrah Düzel; Professor Dr. Eckart D. Gundelfinger; Dr. Michael R. Kreutz; Professor Dr. Volkmar Leßmann; Professorin Dr. Stefanie Schreiber; Professorin Dr. Constanze Seidenbecher; Professor Dr. Oliver Stork; Professor Dr. Markus Ullsperger Spokesperson: Professorin Dr. Daniela C. Dieterich