Aims and objectives :To study the effects of topical Ripasudil on diabetic macular edema in tertiary eye care hospital. Materials and Methods:: Ethics approval was obtained. Written and informed consent was obtained. It is a prospective interventional study of 20 eyes (10 eyes as controls,10 eyes as tests) presenting to our opd. Inclusion criteria for patients in whom ripasudil administered are with DME of FT->300µm with no history of ocular surgery or no photocoagulation, anti VEGF treatment and prescribed ripasudileyedrops 2t/d 4 weeks and followed up for FT measurement. we enrolled 10 eyes as control for comparision with ripasudil with age and sex matched individuals with other criteria as test group. After taking detailed history BCVA, anterior segment and fundus, oct macula with spectral domain oct done. Investigations like Blood pressure, FBS, PPBS, HbA1C, serum creatinine, serum lipid profile were done. Results: After ripasudil administration in those 10 eyes the mean FT decreased significantly from 430 ± 60µm to 380 ± 62 µm (P = 0.003) this change was significantly different from that in the controls, in which the mean FT increased by 1 ± 40µm (P = 0.01). Conclusion: In conclusion, the current findings showed that FT were decreased significantly after 4 weeks after the initiation of ripasudil therapy, suggesting that ripasudil might be effective noninvasive alternative treatment for DME.