Nose-to-Brain Drug Delivery System is an approach to deliver a drug directly in brain through the nose. Intranasal Drug delivery is very beneficial as it avoids first pass mechanism and can achieve greater concentration of drugs in Central Nervous System (CNS) at very low dose. Delivery of a drug through nasal route has been potentially explored as an alternative route for the administration of vaccines and biomolecules. Nose-to-Brain drug delivery system is most widely used for the treatment of Neurological disease such as Alzheimer’s Disease, Parkinson’s Disease, etc. Such Disease affecting CNS and the most difficult to cure due to the presence of Blood Brain Barrier (BBB) which refers as the highly selective semi-permeable border of the epithelium cells surrounded by astrocyte foot processes. The Main Objective of this review report is to study some essential characteristics and their possible obstacles related to Nose-to-Brain Drug Delivery System which includes anatomy and physiology of Nose-to-Brain drug delivery system and also transport of drugs in nose-to-brain via Olfactory Nerve and Trigeminal Nerve Pathways by passing BBB. Keywords: Nose-to-Brain, Intranasal Drug Delivery, Blood Brain Barrier, Olfactory Nerve Pathway, Trigeminal Nerve Pathway.