Antimicrobial stewardship (AMS) teams around the world include pharmacists, and their impact on this is unclear, therefore we aimed by this review to emphasizes their roles. We have conducted a search through electronic databases; Medline and Embase, for all relevant studies related to our topic which was published till the middle of 2022. As antibiotic and vaccine regimens become more complex due to the continuously evolving epidemiology of infectious illnesses, the pharmacist's involvement in battling and preventing infectious diseases is vital. The decline in medication development makes the preservation of already existing antibiotics of utmost importance, emphasizing the roles of pharmacists in optimizing the effectiveness of available treatments. While further training in infectious diseases may be required for certain pharmacist roles in preventing antibiotic resistance, there are numerous others that all pharmacists can assume.