The presented work touches upon the importance of ensuring the biological safety of society and nature in modern times, as well as the points taken into account when ensuring it. It becomes clear that biosecurity is a process aimed at preventing the spread of bioterrorism and infectious diseases, which lead to dangerous consequences and is realized thanks to the participation of each individual. Biosecurity is an even more important issue for Azerbaijan in view of more than 70% of water resources forms at the expense of transboundary sources, and the presence of a state in the neighborhood that openly uses all types of terrorism (political, ecological, biological, etc.). This is clearly shown by the pollution of Okhchuchay, which enters Azerbaijan from the territory of the Republic of Armenia, according to its physicochemical and microbiological indicators. At the same time, the presented work shows the local, regional and global problems for biosecurity and touched upon points that are important to pay attention to their solution.