Nanosponges (NS) with three-dimensional (3D) porous structures, slim size distribution, and high defense potency square measure wide built for cancer medical care and drug delivery functions. They defend the molecular agents from degradation and facilitate to enhance the solubility of oleophilic therapeutic agents/drugs with targeted delivery choices additionally to being attractable to achieve appropriate magnetic options. Nanosponge-based delivery systems are applied for cancer medical care with high specificity, biocompatibility, degradability, and prolonged unharness behavior. several anti-cancer medicine with each deliquescent and oleophilic properties will be loaded or integrated into NS and ultimately increase the characteristics of the medicine. the foremost necessary properties and blessings of NS square measure simply synthesized and modified, offer high drug loading capability together with controlled unharness, increase the solubility and bioavailability of soluble molecules. The eco-friendly techniques for the producing of Nanosponges still have to be compelled to be uncovered additionally to the present ways, like solvent techniques, ultrasound assisted preparation, melting methods, and emulsion solvent diffusion ways. Herein, the recent advancements related to the drug delivery and cancer medical care potential of Nanosponges (chiefly cyclodextrin-based, DNAzyme, and alkyl radical polysaccharide Nanosponges) square measure deliberated, specializing in the necessary challenges and future views. During this critique, application of nanosponges, its preparation ways, polymers used and Cancer medical care were mentioned. Keywords: - Nanosponges, Cancer, Biocompatibility, Ultrasound, Cyclodextrin, etc.