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Genetically adjusted PSA levels for prostate cancer screening

Research datakeyboard_double_arrow_right Dataset 20 Dec 2022Publisher:Zenodo

Authors: Kachuri, Linda; Hoffmann, Thomas J; Jiang, Yu; Berndt, Sonja I.; Shelley, John P.; Schaffer, Kerry; Machiela, Mitchell J.; +16 Authors

doi: 10.5281/zenodo.7460135 , 10.5281/zenodo.7460134

Genetically adjusted PSA levels for prostate cancer screening

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Abstract

Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for genetic determinants of constitutive, non-cancer PSA variation has potential to improve screening utility. We discovered 128 genome-wide significant associations (P<5×10-8) in a multi-ancestry GWAS meta-analysis of 95,768 men and developed a PSA polygenic score (PGSPSA) that explains 9.61% of constitutive PSA variation. Here we provide full GWAS summary statistics for the multi-ancestry meta-analysis and ancestry-stratified summary statistics for ~1.2 million variants used to derive a genome-wide PGSPSA.

Related Organizations

University of California System
United States
Stanford University
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University of California, San Francisco
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Icahn School of Medicine at Mount Sinai
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Memorial Sloan Kettering Cancer Center
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Keywords

GWAS, polygenic score, prostate specific antigen, prostate cancer

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