In our recommendations we focus on the potentials of digitalization as one essential step towards achieving a more sustainable economy, culture, and society. Europe is in a worldwide competition with, e.g., the world powers USA and China. In order to be able to comprehensively understand the potential of digital technologies, their modes of action and their interdisciplinary interaction in socio-technical application contexts must be systematically investigated. Hereby, any socio-technical advances must be accompanied by appropriate communication strategies, since they must be broadly (i) accepted by society and (ii) transferred into business models to ensure their extensive implementation.