The occurrence of oral Kaposis sarcoma (KS) in HIV-seronegative people is extremely rare. Mucosal lesions in VIH seronegative patients have been reported, making it a challenging diagnosis to identify and manage. Here, we present a 54-year-old seronegative patient who underwent radiation therapy as the only course of treatment for a locally advanced palatal mucosal kaposi sarcoma. The outcomes of the treatment in terms of tumor control and the immediate relief of our patients symptoms illustrate its effectiveness and support kaposi sarcoma radiosensitivity.