This study examined the effect of corporate social responsibility on the profitability of oil and gas firms in Nigeria. The study specifically examined the effect of corporate social responsibility expenditures on return on asset, turnover and net asset of oil and gas firms in Nigeria. Data for the study was sourced through annual reports of the sampled oil and gas firms for a period of 10 years spanning through 2011 to 2020. Data collected were analysed using multiple regression analysis, the study revealed that the t-statistics of ROA and TOV is -0.896885 and -3.485975 which greater than 2 and the p-value is 0.0363 and 0.0014 which is less than 0.05, it shows that CSRE has a negative and significant effect on ROA and TOV. While the t-statistics of NA is -0.651440 which is greater than 2 and the p-value is 0.5193 which is greater than 0.05, the study conclude that CSRE has a positive and insignificant effect on NA. Based on the findings, the study recommends that 6he companies should expand their CSR activities by going into other areas like health, education, charity giving, instead of focusing on a particular activity. The organizations should provide adequate amenities to their immediate environment. The companies should improve on their services; most times the network reception is very poor.