We have studied the assessment of the significance of various risk factors for the birth of a child with congenital developmental anomalies in the Bukhara region. A method for the rational formation of risk groups among pregnant women is proposed, which will increase the level of timely diagnosis of congenital malformations and reduce perinatal and infant mortality in the Bukhara region. The risk factors were folate deficiency (24.9%), vitamin D deficiency (9.8%), zinc deficiency (12.9%) and chronic iodine deficiency (7.5%). In the course of the analysis, congenital malformations of the nervous system were revealed (34.03%), the second place was taken by multiple congenital malformations - (19.9%), the third - congenital malformations of the circulatory system (2.27%).