Structural and Functional Relationship of Macrolide Polyene Antiobiotics in Plasmatic and Bilayer Lipid Membranes

This review is dedicated to the biological activity of polyene fungicide antibiotics in cell membranes, which shows the changes of physical and chemical characteristics and parameters of cell and bilayer lipid membranes at the presence of these drugs. Membrane activity of PA is in the interaction with sterols connected with cell membranes. The formation of ionic channels from both molecules – PA and cholesterol is in the base of action’s mechanism.

Keywords

Polyene antibiotics (PA), bilayer lipid membranes (BLM), ion channels, membrane conductivity

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