Impetigo is a highly contagious illness of the superficial epidermis that typically affects children between the ages of two and five, but can affect anybody. Currently affects around 162 million children worldwide. Lack of agreement on the most effective treatment strategy for impetigo and rising antibiotic resistance continue to motivate research into novel and alternative treatments. We combed PubMed, MEDLINE via EBSCOhost, CINAHL via EBSCOhost, Web of Science, and Embase via Scopus for studies published by February 29, 2022. There is no conventional treatment for impetigo, and there are numerous potential choices. Mupirocin and fusidic acid are efficient topical antibiotics that may be superior to oral antibiotics. Patients with significant illness should be considered for oral antibiotic therapy.