We investigated the influence of wormwood-wild rue mixture with high anthelmintic effect on the diuretic process in sheep and on the physical and chemical properties of the urinary excretion of the sheep fed with (6 g / kg), three and fivefold increased therapeutic dose (18 and 30 g / kg) of the mixture. No pain was observed during urination in the experimental animals. The urine of the experimental animals was clear, light yellowish in color, there was no smell. The density of urine in animals fed with the mixture at a dose of 30 g / kg was 1.029, pH was 8.48, which is the norm. Proteins, sugars, ketone bodies, bilirubin were not found in the urine of animals undergoing experiments. In the tested urine, individual blood vessels appeared, and a small amount of indican and urobilins was found. The findings show that wormwood does not have a toxic effect on the physical and chemical properties of urine in sheep.