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Metformin affects alternative splicing of the estrogen receptor alpha gene in breast cancer cells

descriptionPublicationkeyboard_double_arrow_right Article 20 Nov 2022 English Publisher:Zenodo

Authors: Yoshihiro Harada; Tomoko Tanaka; Yuriko Hamaguchi; Yuta Horita; Masayoshi Mori; Masayoshi Mori; Munechika Enjoji; +1 Authors

doi: 10.5281/zenodo.7412527 , 10.5281/zenodo.7412528

Metformin affects alternative splicing of the estrogen receptor alpha gene in breast cancer cells

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Abstract

ABSTRACT Metformin ameliorates insulin resistance and reported to have prophylactic potential in breast cancer. The estrogen receptor-alpha gene is known to be alternatively spliced to the ERα46 isoform with decreased expression in tamoxifen-resistant breast cancer cells. We show here that metformin had a differential effect on its alternative splicing in MCF-7 and its tamoxifen-resistant derivative, TAMR1 cells. Metformin altered the tamoxifen-induced expression of ERα46 and treatment of cell-transplanted nude mice showed decreased tumor weight only in TAMR1 cell tumors. This is the first report to show metformin specifically involved in alternative splicing of genes in breast cancer cells. Keywords: Estrogen receptor-alpha (ERα), estrogen, tamoxifen, metformin

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Fukuoka University
Japan

Keywords

Estrogen receptor-alpha (ERα), estrogen, tamoxifen, metformin

1 Research products, page 1 of 1

Gene expression analysis in tamoxifen resistant ER+ breast cancer cell lines
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