The objective of this study was to preparation and development of Diclofenac loaded aloevera gel nanoparticles for transdermal drug delivery system. The application of CCD is a useful tool for optimizing DCloaded alovera gel nanoparticles prepared by the emulsion solvent evaporation technique. The optimized nanoparticles obtained displayed an average particle size of 226.83 nm with a norrow polydispersity index (0.271), an EE of 49.9 % and a slow and prolonged drug release over a period of 24 hours. Ethylcellulose nanoparticles of Diclofenac sodium can be of significant practical use for a sustaining drug release and decreasing side effects.