Before there were contemporary therapies, herbal medicines were employed to treat acne and other skin disorders. Even though there hasn't been much research on many herbal remedies, there is a tonne of anecdotal evidence. Because of their superior therapeutic effect and lower toxicity, herbal medicines are better. They lessen toxicity by reducing the frequency of doses. Natural medications from active plant extracts, essential oils, phytomolecules, and extracts are included in herbal medicines. In light of this, the current study's objective is to evaluate the anti-acne potential of the medicinal plant Sterculia lychnophora. The ascorbic acid and extracts have demonstrated dose-dependent DPPH radical scavenging. The IC50 values for the standard and extracts for radical scavenging were 19.29 and 88.37, respectively, for ascorbic acid>extract. Propionibacterium acnes. The Sterculia lychnophora hydroalcoholic extract's also showed the potent effect against diabetes. According to these documented data, hydroalcoholic extract exhibits strong anti-acne efficacy. The current study came to the conclusion that Sterculia lychnophora has important secondary metabolites that are in charge of its varied pharmacological functions. It also demonstrated that the Sterculia lychnophora's metabolites may be extracted most successfully using the polar solvent hydroalcoholic. Key words: Sterculia lychnophora, Propionibacterium acnes, Antioxidant, antidiabetic, Anti acne