Populations around the world use medicinal plants to treat numerous diseases and ethnopharmacological information serves as a starting point for developing new drugs. The evidence of the therapeutic properties of zerumbone from bitter ginger, which are mainly secondary metabolites, is important information that can help in the search to discover new drugs. From a commercial point of view, a positive aspect is that ginger is easy to cultivate and it has a lot of pharmacological properties. This review article highlights the phytochemical & pharmacological aspects of Zingiber zerumbet. The results from all the studies and research mentioned in this review paper are definitive evidences that ZER is a powerful compound in the treatment of cancer and several other diseases and it possesses different beneficial in vitro and in vivo biological activities. It is nevertheless essential to do more animal studies and human clinical trials to determine the efficacy, safety and usefulness of Zingiber zerumbet as an intended pharmaceutical drug.