Tulsi popularly known as Holy basil Botanically it is ocimum sanctum linn.Tulsi is the aromatic plant in our mother India it is considered as holiest plant and home remedy for various illness.It belongs to the family Lamiacae. Traditionally, the fresh fruits and leaf’s of tulsi juice were commonly used in the treatment of cough and demulcent. It is widely used in the Ayurveda and Siddha system of medicine. Tulsi is the legendary Incomparable one of india. tulsi is taken as many forms as herbal tea, dried powder, fresh leaf,or mixed with honey or ghee .For centuries, the dried leaves of tulsi have been mixed stored grains to repel insects and also this plant known to possess anti-inflammatory, antimicrobial and immunomodulatory. The dried powder of tulsi [100g] was placed in the thimble of Soxhlet apparatus .500ml of distilled water was used as a solvent. The extract was concentrated using rotavapor. Then the extract was dried using digital water bath till the green residue was obtined. The percentage yield was 8%,7%.and5%w/w respectively. The test sample was subjected to phytochemical analysis order to find out the presence of phytochemical constituents. So the present review summarizes the comprehensive information concerning the traditional use, properties and phytoconstituents of tulsi. Key words: Tulsi, Anti-inflammatory, Anti-microbial, and Immunomodulatory.