Hereditary spastic paraplegia (HSP) most often "masks" as spastic diplegia with cerebral palsy (CP), so it is difficult to differentiate them from cerebral palsy. The aim of the study is to identify the clinical and anamnestic features of NSP in a comparative aspect with cerebral palsy, spastic diplegia. In patients with NSP, movement disorders appear later by the age of 3 years and slowly progress thereafter. Already at the age of 10-12 years, patients are forced to use auxiliary means of transportation. And with cerebral palsy of spastic diplegia, compared with NSP, from birth, the clinical picture is characterized by a lag in psychomotor development and a non-progressive course. In case of clinical verification of NSP disease, it is necessary to conduct confirmatory molecular genetic diagnostics.