References: 1. Abaev Yu.K. Wound infection in surgery. Minsk: Belarus.-2013. -293 p. 2. Alekhina S.P., Shcherbatyuk T.G. Ozone therapy: Clinical and experimental aspects. - Nizhny Novgorod: Publishing house "Litera", 2015. - 240 p. 3. Aliev S.D., Aliev M.Kh., Askerov I.E. et al. About the mechanisms of blood and lymph clotting disorders in acute peritonitis //Al.immun., 2015 v.9.-№1.-p.50. 4. Alsynbaev M.M., Korzhenevsky A.A., Medvedev Yu.A. The frequency of isolation of individual pathogens of purulent-septic surgical infections in patients with various types of immunodeficiency // Allergol. Immunology., 2018.- v.9.-№1.-p.52. staphylococcus, proteus, klebsiela. 5. Alyavi A.L., Rakhimova D.A. Endothelial dysfunction of peripheral vessels in patients with chronic obstructive pulmonary disease complicated by chronic pulmonary heart disease and possibilities of ozone therapy. Toolkit. - Tashkent, 2017, - S. 10-14. 6. Bazhanov N.N., Kozlov V.A., Robustova T.G. The state and prospects for the prevention and treatment of purulent-inflammatory diseases of the maxillofacial region // Dentistry.-2017. Media Sphere Publishing House. Moscow.-№2.-p.15-19 7. Beloborodov V.B. Actual aspects of antimicrobial therapy of surgical infections// Infections in surgery. Publishing house "Esculapius". St. Petersburg-2015.-vol.1. No. 2. With. 28-30. 8. Belkova Yu.A.Pharmacoepidemiological and microbiological aspects of optimizing the treatment of skin and soft tissue infections on an outpatient basis. Abstract dis...c.m.s., Smolensk, 2006.- 23 p. 9. Boyarinov G.A., Gordetsov A.S. Solubility and decay of ozone in physiological solution // Nizhny Novgorod medical journal. -2015.- №2.-p.40-50. 10. Bulavkin V.P., Okulich V.K., Konopelko E.A. Antibacterial therapy of chronic osteomyelitis of long bones. /International scientific and practical peer-reviewed journal "Immunology, Allergology, Infectology". "National Academy of Mycology" Moscow-2011.-№3.- p. 53-55. 11. Grechko V.N. Combined application of complex ozone therapy and phototherapy with transformed red light in surgery (experimental clinical study). Nizhny Novgorod, Vector-TiS, 2015, 303 p. 12. Demidenko V.A., Lazarev A.I., Konoplya A.I. Immunological rehabilitation of patients with complicated forms of chronic salpingo-oophoritis in the postoperative period.//Kursk scientific-practical. Bulletin "Man and his health" - Kursk, 2017. No. 2.-p.52-59. 13. Zhumadilov Zh.Sh., Berikhanova K.E., Aldyngurov D.K. Diagnostic and prognostic significance of cytokines determination in case of extensive purulent-necrotic inflammations of soft tissues // Allergol. Immunology. Publishing house "Medicine-Health". Moscow. 2015. v.9.-№1.-p.51. 14. Zaitsev V.Ya., Maslennikov O.V., Kontorshchikova K.N. Practical ozone therapy. - N. Novgorod: Vector-TiS, 2015. - 52 p. 15. Zemskov A.M., Maslennikov O.V. Guide to ozone therapy. - N. Novgorod: Vector-TiS, 2017. - 326 p. 16. Zmyzgova A.V., Maksimov V.A. Clinical aspects of ozone therapy//M. 2018. 287 p. 17. Karimov M.M., Abdullaev A.Kh., Sabirova G.N. et al. The use of ozone therapy in the rehabilitation treatment of patients with chronic hepatitis. Guidelines. T., 2007., 9 p. 18. Kulikov A.G., Turova E.A., Kiseleva O.M. The effectiveness of various methods of ozone therapy in vascular complications of diabetes mellitus // Vopr. Balneology, physiotherapist. and LFC. 2012. No. 5. p.17-20 19. Malenkov A.G. The influence of ozone on the human body and the mechanisms of its therapeutic action http://magericmed.net/vliyanie-ozona-na-organizm-cheloveka-i-mexanizmy-ego-lechebnogo-dejstviya.html. Moscow (undated). 20. Rakhimova D.A., Kasimova G.M, Kayumova Y.D. Condition metabolic balance disturbance in patients with cor pulmonale: prevalence, diagnosis, risk factors. "Journal of life-sciences". – Argentina, 2012. - №2. - Р. 164-167. 21. Rakhimova D.A., Kasimova G.M. Estimation of psychovegetative factors of regulation in patients with chronic obstructive pulmonale diseases . "Journal of life-sciences". – Argentina, 2012. - №4, - Р. 457-461. 22. К вопросу диагностики пародонтита: существующие возможности и клинические потребности / Е.Н. Светлакова, Е.А. Семенцова, Л.Г. Полушина, Ю.В. Мандра, В.В. Базарный // Здоровье и образование в XXI веке. – 2017. – Т. 19, № 3. – С. 34–37. 56. 23. Субанова, А.А. Особенности эпидемиологии и патогенеза заболеваний пародонта (обзор литературы) / А.А. Субанова // Медицина. – 2015. – Т. 15, № 7. – С. 152–155. 24. Shcherbatyuk T.G. Free radical activity of blood plasma depending on the concentration of ozone and the duration of ozonation //Appendix to NMW. Ozone therapy. Nizhny Novgorod Medical Journal, Nizhny Novgorod State Medical Academy. G. N. Novgorod. 2015. pp.52-53.

Abstract Article is devoted history, status and prospects for the prevention and treatment of purulent-inflammatory diseases of the oral cavity in bronchial asthma mechanisms of action and to use ozone-therapy at various diseases.