Background: Low levels of zinc have been linked to thyroid function in the blood in several ways, but the link between zinc deficiency and thyroid disease has yet to be confirmed. This study aimed to estimate the serum zinc levels status in a sample of patients associated with hypo- and hyperthyroidism compared with normal thyroid function. Materials and Methods: The study included 38 patients who suffered from thyroid disorders, hyperactivity, and they were assessed by the members of the Endocrine Unit for a definitive for the diagnosis of the cause of thyroid dysfunction. As well as 12 healthy people who were used as a control group. Results: serum zinc levels were significantly lower in patients with hypothyroid 67.719(45.40-94.63) compared to hyperthyroid 90.21(53-101.22) and controls 90.27(83.20-100.71). (P< 0.001). Similarly, as compared to the control group, the results revealed a statistically significant increase in TSH serum levels in hypothyroidism patients and a significant lowering in hyperthyroidism patients (P< 0.002). A negative association between TSH and zinc was found (p =0.001). The study did not show a significant association between TSH and T3, T4 with zinc in the controls group or the hyperthyroid patients. Even though there is a variation in median values among these groups of patients. The current study established no significant difference in serum levels of T3 in hypo- and hyperthyroidism patients (P=0.202) when compared to the control group. In comparison to the control group, the data revealed a statistically significant decrease in T4 serum levels in hypothyroidism patients and an increment in hyperthyroidism patients (P< 0.005). Conclusion: hyperactivity and hypothyroidism can both be caused by low zinc levels in the blood. To improve zinc status in this group, efforts to correct abnormal levels of thyroid hormones may help.