The fungus Mucorales causes a condition known as mucormycosis, which is an angio invasive infection. Although it is an uncommon condition, it is becoming more prevalent in those with immune impairment or poorly controlled diabetes mellitus. Even if vigorous therapy is administered, an overall higher death rate is recorded for the Rhino-orbito-cerebral, cutaneous, dissemination, intestinal, and pulmonary kinds. This review's primary goals and objectives were to provide a summary of mucormycotic disease, its etiopathogenesis, the mortality rate of rhino cerebral mucormycosis, and new developments in therapeutic and diagnostic approaches.