Chronic obstructive pulmonary disease (COPD) is now considered a preventable and treatable disease. Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease in patients with bronchial obstructive disease that has significant manifestations in the lungs and beyond. It is characterized by constant restriction of an air stream. Usually, the clinical course of the disease increases and depends on the pathogenic action of toxic particles or gases that cause chronic inflammation in the lungs. Identification of pathogenetic mechanisms that cause the occurrence of complications, and their treatment is one of the urgent problems of our time. Chronic obstructive pulmonary disease in obese patients, complicated by chronic heart failure, is characterized by the predominance of pathogenetic mechanisms of endothelial dysfunction, depending on the stage of COPD and the stage of CHF. The more severe COPD is, the higher the levels of pro-inflammatory cytokines, which indicate the severity of endothelial dysfunction. Also, the higher the stage of CHF, the higher the level of proBNP.