Background: To maintain immobility of children for good quality computed tomography (CT) scans, sedation may be used. Present study was planned to compare the efficacy of oral triclofos and oral midazolam in children undergoing CT. Methodology: The prospective, comparative, randomized Indian study was conducted in Department of Anaesthesia at a J.J. Hospital and Grant Medical college. Study population was paediatric subjects between 2 years and 5 years (both inclusive) with ASA-I, exhibiting fearful or refractory behaviour at previous CT Scans. Oral triclofos 100 mg/kg was given to one group (100 patients) and oral midazolam 0.75 mg/kg in other group (100 patients) in preoperative room with facility of oxygen and multipolar monitor. Standardized scoring systems (Ramsay Sedation Scale, Aldrete Recovery Score) were used for evaluation. Vascular parameters, time of sedation onset and duration of recovery were also assessed. Results: Mean age and gender distribution were comparable between study groups (p>0.05). On comparing heart rate, systolic and diastolic BP between the Midazolam and Triclofos groups at all time-points, no significant difference was found (p>0.05). Mean sedation score and recovery score in the Midazolam group were found to be significantly higher compared to Triclofos group (p<0.05). Mean onset of sedation was found to be significantly quicker in the Midazolam group (p<0.05). In addition, the mean duration of sedation and duration of CT scans were significantly lower in the Midazolam group (p<0.05). Conclusion: Midazolam was found to have a better sedative profile compared to Triclofos in paediatric patients undergoing CT.