The study was conducted to study the possible relationship of job satisfaction and role stress with organizational effectiveness. The study was based on the primary data collected through print outs of self-administrated questionnaires from employees of textile industry. The sample size was 400 whereas the analysis was performed on the data collected from 367 employees working in textile industry of Pakistan. The measurement scales were adopted from the previous studies. The study followed the cross sectional, statistical, ex-post facto, and field setting research design. To ensure the validity in contextual arrangement of the textile industry the confirmatory factor analysis was performed by using AMOS. Moreover, structural equation modeling was performed to test the studied hypotheses. The relationship of job satisfaction with organizational effectiveness was found positive and significant whereas the relationship of role stress with organizational effectiveness was found significant and negative.