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STUDY OF THE SPECIFIC ANTI-INFLAMMATORY ACTIVITY OF NEW DERIVATIVES OF MULTI-LIGAND BIOACTIVE COORDINATION COMPOUNDS BASED ON DICLOFENAC

descriptionPublicationkeyboard_double_arrow_right Article 24 Nov 2022Publisher:Zenodo
Authors: Obidova N.J; Makhmudov L.U; Abdugafurova D.G; Ibragimov B.T;

doi: 10.5281/zenodo.7353411 , 10.5281/zenodo.7353410

STUDY OF THE SPECIFIC ANTI-INFLAMMATORY ACTIVITY OF NEW DERIVATIVES OF MULTI-LIGAND BIOACTIVE COORDINATION COMPOUNDS BASED ON DICLOFENAC

Abstract

Abstract: The article studied the specific anti-inflammatory activity, acute toxicity and accumulation of samples of new complex compounds synthesized on the basis of diclofenac, which are supposed to have increased bioavailability and reduced toxicity. The study of the specific anti-inflammatory activity of new diclofenac-based complexes showed that diclofenac, metal complexes (Zn2+, Cu2+, Ni2+) based on it had antiexudative activity similar in its effectiveness. According to the results obtained, these metal complexes exhibit an anti-inflammatory effect, which decreases in the following order: Dicl-Ni-EDA > Dicl-Zn-EDA > H-Dicl >Dicl-Cu-EDA. The formation of the Dicl-Ni-EDA complex makes it possible to enhance anti-inflammatory activity.

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Keywords

Keywords: anti-inflammatory activity, complex, compounds, diclofenac, antiexudative activity, drugs, biological properties

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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