Aim: Evaluate safety and efficacy of laparoscopic resection vs open surgery for the curative care of patients having tumors of right or left colon. The security and brief advantages of laparoscopic colectomy for cancer patients are still being debated. The multicenter COLOR experiment was conducted to examine the effectiveness and safety of laparoscopic excision vs open resection for the curative therapy of individuals having cancer of right or left colon. Methods: Laparoscopic surgery was allocated to 629 individuals randomly, whereas open surgery was randomized to 623 individuals. The major goal was to determine cancer-free survival one year following surgery. Short-term illness and death, the sum of positive resection margins, local return, port-site or wound-site relapse, metastases, survival rates, also overall blood loss following operation also were secondary outcomes. The evaluation was carried out with the purpose to treat in mind. Clinical features, and operational results, including postoperative prediction remain all discussed here. Results: People undergoing laparoscopic resection lost less blood than some of those undergoing open excision (median 100 mL [range 0-2710] vs 178 mL, p00002), despite the fact that laparoscopic surgery took 35 minutes longer (p00001). For 93 (18%) of laparoscopic individuals, transition to open surgery was required. The quantity of excised lymph nodes and length of the resection oral and aboral bowel were identical among sets. When contrasted to open colectomy, laparoscopic colectomy significantly related overall faster bowel sufficiently effective (p0.0002), the requirement for more painkillers, and a shorter hospitalization (p00002). Both mortality and morbidity were not different among cohorts 30 days following colectomy. Conclusion: Laparoscopic surgery is performed to safely and completely remove cancer from the right, and left especially sigmoid colons. Keywords: Laparoscopic Resection vs Open Surgery, Right or Left Colon, Safety and Efficacy.