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A IMPORTÂNCIA FARMACOTERAPÊUTICA DOS TKIS NA LEUCEMIA MIELOIDE CRÔNICA

Authors: Juliana Rocha Pires¹ Prof. Me. Ademilton Costa Alves²;

A IMPORTÂNCIA FARMACOTERAPÊUTICA DOS TKIS NA LEUCEMIA MIELOIDE CRÔNICA

Abstract

A leucemia mielóide crônica (LMC) é uma doença mieloproliferativa, ela é um tipo de câncer não hereditário que se desenvolve na medula óssea, sendo acometido na maior parte dos casos, em adultos. A LMC pode ser dividida em três fases clínicas, iniciando pela fase crônica, seguida da fase acelerada e culminando na crise blástica. Se caracteriza pela presença de um cromossomo denominado Philadelphia pela translocação do cromossomo 9 e do cromossomo 22, resultando em um gene híbrido o “BCR-ABL”. A Leucemia mieloide crônica possui terapias como: quimioterapia, transplante de medula óssea, e os inibidores da tirosina quinase – TKIs como tratamento padrão atual para pacientes portadores dessa malignidade.

Keywords: BCR-ABL; Treatments; Tyrosine kinase inhibitors.

Keywords

BCR-ABL; Tratamentos; Inibidores da tirosina quinase.

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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