The coronavirus disease 2019 (COVID-19) pandemic has caused increasing challenges for healthcare professionals globally. However, there is a dearth of information about these challenges in many developing countries. This study aims to explore the challenges faced by healthcare professionals during COVID-19. There has been minimal research into the role of HCWs and their experiences, as well as those of other staff working with HCWs in general practice. Lessons may be learned from their role and evidence of their effectiveness in hospital settings. Such research highlights blurred and contested role boundaries and threats to professional identity, which have implications for teamwork, quality of patient care, and patient safety. Drawing on the limited research in general practice, the challenges and benefits of developing the HCWs role in general practice are discussed. The findings highlight the common challenges faced by healthcare professionals during the COVID-19 outbreak. This implies the need to support adequate safety kits, protocols, and support for both physical and mental health of the healthcare professionals.