Amaranthus roxburghianus is one of the traditionally well-known plants with outstanding therapeutic properties, and is used mostly in treating different diseases in India. Thus, based on these medicinal properties, various investigations have been undertaken in order to appraise the pharmacological activities and the chemical composition of these species. Here, we elucidate the analgesic and anti-inflammatory activity of Amaranthus roxburghianus ethanolic leaves extract. phytochemical screening of Amaranthus roxburghianus extract showed the presence of alkaloids, Carbohydrates, Glycosides, Flavonoids, Tannins, Proteins, Amino Acids. the ethanolic leaves extract of Amaranthus roxburghianus, possess peripheral and central analgesic activity in animal model. The Amaranthus roxburghianus leaves extract shows anti-inflammatory activity in different animal model. Flavonoids and tannins are the major constituents of Amaranthus roxburghianus leaves, which may be responsible for its Analgesic, Anti-inflammatory activity. KEYWORDS: Amaranthus roxburghianus, Phytochemical screening, Analgesic activity, Anti-inflammatory activity