Hyperlipidemia is a disorder of lipid metabolism manifested by increase of plasma concentrations of the various lipid and lipoprotein fractions such as increase of serum total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG) concentrations, and a decrease in the high-density lipoprotein (HDL) concentration. The aim of the present study is to promote a potential new herbal formulation to prevent atherosclerosis at a low cost. In this study ethanolic extract of Amaranthus roxbhurgianus- showed positive to following phytochemical constituent’s Carbohydrates, Glycosides, Flavonoids, Proteins, Sterols. The significant reduction in serum cholesterol,TG,LDL, ,AI, and also increased in total HDL level in the different dose level(100,200 mg/kg) in high cholesterol diet. Hence it is going to be concluded that the potential benefits of the extracts of Amaranthus roxbhurgianus has been demonstrated well in advance and can be used further to demonstrate the antihyperlipidemic as well as controlling of both triglyceride levels and reducing the risk of factors of cholesterol inducers. The aforementioned results of the research suggest that the Amaranthus roxbhurgianus found to have the potential antihyperlipidemic action. Keywords: Anti-hyperlipidemic activity, Amaranthus Roxbhurgianus, Albino rats