Hyperlipidemia is a disorder of lipid metabolism manifested by increase of plasma concentrations of the various lipid and lipoprotein fractions such as increase of serum total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG) concentrations, and a decrease in the high-density lipoprotein (HDL) concentration. Hyperlipidemia is the key risk factor for cardiovascular disorders and has been reported as the most common cause of death in developed as well as developing nations. And hence only in this approach, intention has been to evaluate the anti- hyperlipidemic and antioxidant activity of Ixora chinensis leaf extract on High fat diet-induced hypercholesterolemia and triton induced hyperlipidemia models. . It has been observed from our experimental research, there has been a remarkable and significant activity observed, against the anti-hyperlipidemic activity. Futuristic scope of this study will be extended to the investigation and isolation of the specific components responsible for antihyperlipidemic trait. Keywords: Anti-hyperlipidemic activity, Leaves, ixora chinensis, Albino rats