Nephroprotective agents are material that has potential to minimize the effects of nephrotoxic agents. Medicinal plants have curative properties due to the presence of various complex chemical substances. Morinda citrifolia L (Noni) also known as Indian mulberry is a common plant known to grow in the tropical countries. The present study was focused on the investigation of Nephroprotective activity of the ethanolic extract of fruit Juice of Morinda citrifolia on cisplatin induced nephrotoxicity in Wistar albino rats. The phytochemical investigation revealed the presence of carbohydrate, alkaloids, flavanoids, glycosides, saponins, tannins, phenols and anthroquinone in EEMC. The administration of cisplatin during experimentation is effectively induced apoptosis and necrosis, which was similar to acute renal failure in human. Therefore, it is an effective and an ideal model for nephrotoxicity research. The evaluation of renal parameters on nephrotoxic rats with EEMC showed significantly elevate the attenuated body weight, urine volume, creatinine clearance and significantly reduce in elevated serum creatinine level, which supports its Nephroprotective activity. Key words: Nephroprotective activity, Mornido citrofolia, Albino rats, phytochemical screenin