This contains the data for the manuscript Feugere et al., "Heat induces multiomic and phenotypic stress propagation in zebrafish embryos" (2023). Zebrafish embryos were exposed to thermal stress ("TS") and stress metabolites ("SM") released by heat-stressed conspecifics in a two-way factorial design ("TSxSM"). The folder includes raw molecular data (cortisol levels, HSP70 protein levels, and gene expression acquired with LAMP and RNA-seq) and raw phenotypic data (morphology, hatching, survival, and behaviour) of zebrafish Danio rerio at 1 day and 4 days of development. The .csv files contain all quantitative data, whilst the .tab files contain the gene count data required for gene expression analysis. The data were analysed in R using the code shared in the "TSxSM2.stats.Rmd" file. The "Metadata" document provides the reader with an extensive description of each file.