Plants either in raw form or their isolated bioactive constituents are utilized as complementary and alternative medicine in various disorders. The present study was undertaken to evaluate in vitro antioxidant and antipyretic activities of the Hydroalcoholic extract of the leaves of Mimosa pudica. DPPH scavenging activity was measured by the spectrophotometer for ascorbic acid and hydroalcoholic extract of Mimosa pudica. The yeast-induced hyperthermia in the rat model was, therefore, employed to further investigate the antipyretic activity of mimosa pudica. Extract was administered i.p. 30 min before the injection of the pyrogen. The rectal temperature of animals was recorded at 1 h intervals for 4 h following the administration of drug or plant extract. This result seems to support the view that the plant has some influence on prostaglandin biosynthesis, since prostaglandin is believed to be a regulator of body temperature. Key words: Mimosa pudica, Hydroalcoholic, Antioxidant and Antipyretic activity