The aim of this study was to design and evaluate the mouth dissolving dosage form of domperidone drug as an anti-emetic drug. The orodispersible tablets of domperidone were prepared by direct compression method. Formulation of tablets was carried out using different types of super disintegrating agents and excipients. The obtained calibration curve was straight line. The curve was obtained in pH 6.8 at the maximum wavelength of 287 nm. The calculation of in-vitro drug release study was based on the calibration curve. The Mouth dissolving tablet are beneficial for geriatric and pediatric patients. The Sodium starch glycolate as Superdisintegrant shows better results for Mouth dissolving tablet. Therefore F5 formulation is the best formulation of Mouth dissolving tablet among all formulations. The disintegration time and in-vitro drug release is good. About 98.5% drug was released within 5 minutes. The disintegration time and in-vitro drug release is good. The percent drug release of Mouth dissolving tablet (F5) was 98.5 % at the end of 5 minutes. Keywords: Friability, Hardness, Disintegration, compression, drug release