Objective: To explore the therapeutic effect of acupuncture combined with joint mobilization in the treatment of periarthritis of the shoulder. Methods: According to the random number table method, 46 patients with periarthritis of the shoulder were randomly divided into two groups, with 23 patients in each group. Acupuncture combined with joint mobilization (combination group) and acupuncture alone (control group) were used respectively. The visual analogue scale (VAS), range of motion (ROM), and efficacy were evaluated before treatment, 4 weeks after treatment, and 8 weeks after treatment in each group. The therapeutic effect, pain, and changes in shoulder joint function were compared between the two groups. Results: After 4 weeks of treatment, the VAS scores of patients in both groups were lower than before treatment and the combination group improved better than the control group (P<0.05); the ROM scores of patients in both groups were higher than before treatment and the combination group scored higher than the control group in the forward flexion, back extension and abduction directions (P<0.05); after 8 weeks of treatment, the VAS scores of patients in both groups were lower than before treatment and 4 weeks of treatment and the combination group improved better than the control group (P<0.05); the ROM scores of patients in both groups were higher than those before and at 4 weeks of treatment, and the scores in all directions in the combination group were higher than those in the control group (P<0.05). Conclusion: Acupuncture combined with joint mobilization can better alleviate the pain of patients with periarthritis of the shoulder, and can also more effectively improve the limitation of shoulder joint activity and improve its function