A 60-year-old male patient reported to the Outpatient Department of Kayachikitsa, with the complaints of frequent loose, watery, frothy, and foul-smelling stool stained with mucous and blood with tenesmus. Other associated complaints were loss of appetite, distension and pain in the abdomen, headache, insomnia, and generalized weakness. The patient was diagnosed as Irritable Bowel Disease consistent with Ulcerative Colitis. A combination of Lavanbhaskar Churna, Yashtimadhu, Lodhra, Sariva, Patha, Dhamasa 300 mg each powder three times a day, along with tablet Praval Panchamrut 250 mg 2 tablets three times a day and tablet Kamadudha Rasa 250mg 2 tablets three times a day before food was administered for 45 days. After the 45 days of treatment, a significant response in various symptoms such as frequent defecation, blood, mucous stained stools, loss of appetite, abdomen distension, headache, and insomnia were found.