Diagnosis of tuberculosis (TB) is difficult, since symptoms are often very unspecific or lacking. However active, prompt and accurate diagnosis is the key element in the public health response to tuberculosis and the cornerstone of tuberculosis control. We conducted narrative review through the litruture, for all studies that were published up to the beginning of 2021. Different diagnostic procedures are required for an accurate diagnosis of tuberculosis. Although chest radiography is a significant tool in identifying tuberculosis, radiography alone cannot establish tuberculosis diagnosis. CT scanning is utilized to identify TB from other diseases in individuals who do not have abnormal chest radiography but are clinically suspected of having active TB. The radiological appearance of patients is mostly determined by their immunological status, and caves and widespread disease foci are frequently found. Microscopic detection of acid-fast mycobacteria from any fluid (particularly sputum) as well as isolation and characterisation of mycobacteria in culture are examples of laboratory diagnostic procedures. The pathogens can then be classified based on the morphology of their colonies, growth patterns, and biochemical properties.