ABSTRACT Liver is a vital organ for metabolism and it is affected due to various diseases and toxic products. It also plays an important role as bio Transformer of xenobiotic which are more toxic and more reactive substances. Though there are some liver tonics in modern medicine, Siddha medicine has innumerable formulations to protect the liver. Jaundice is an important sign of liver disorder. Hepatocellular carcinoma is the commonest cause of liver cancers which leads to 5th common cause of cancers affecting mankind. Liver cirrhosis is the common cause of liver disease in India. There is a need of safe hepatoprotective drug from Siddha system of medicine. The available information was collected from various Siddha and modern literature, scientific databases such as PubMed, Science Direct, Scopus, Web of Science and Google Scholar etc. One such hepatoprotective drug is Saman Chooranam. But there is no sufficient collective literature report and scientific validation of this formulation. The significance of this review is aimed to provide a brief and collective scientific evaluation of the key active phytochemical components and its pharmacological actions for the possible development of this formulation Saman Chooranam in future perspective. This review reveals that the traditional use, phytochemistry and pharmacological profile of Siddha herbomineral formulation of Saman Chooranam thereby identifying the research lacuna and future steps regarding this drug. Keywords: Siddha medicine, Saman Chooranam, Hepato protective, Herbomineral.