The most popular route of administration of a Drug is oral route, but some conventional dosage forms have its own problems like short gastrointestinal transit time, fluctuations in blood plasma levels, low bioavailability problems. Tablets are the most commonly and widely used dosage form. Cefpodoxime Proxetil is a class of medications called third generation Cephalosporin Antibiotics, it is used to treat certain infections caused by bacteria such as Bronchitis, Pneumonia, Gonorrhea and infections of the Skin, Ear, Sinuses, Throat, Tonsils and Urinary Tract. It has Minimum dose of 200 mg and 800 mg Maximum in a day. Many researchers developed Cefpodoxime Proxetil matrix dosage form which can give a prolonged therapeutic effect. But, in this formulation Cefpodoxime Proxetil is combined with three different Natural Gums [Karaya Gum, Acacia Gum and Guar Gum] they also act as Natural Binders in the dosage form due to their good binding abilities. The formulation was developed as a sustained release matrix dosage form in an oral tablet with a dose of 300 mg/tablet. Pre and Post- Compression parameters were done in the study, and In-Vitro drug dissolution study were conducted, but further In-Vivo study is Required/Recommended, And Future research is recommended.