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Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic

Name: Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic
Keywords: aDNA, metagenome binning, metagenomics, natural products, dental calculus, genome reconstruction, paleofuran, paleolithic, paleobiology, biosynthetic gene clusters

Research datakeyboard_double_arrow_right Dataset 04 Feb 2023 English Publisher:Zenodo

Authors: Klapper, Martin; Hübner, Alexander; Ibrahim, Anan; Wasmuth, Ina; Borry, Maxime; Haensch, Veit; Zhang, Shuaibing; +16 Authors

doi: 10.5281/zenodo.7244131 , 10.5281/zenodo.7244132

Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic

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Abstract

De novo assembly of ancient metagenomes to reconstruct biosynthetic machinery and access Pleistocene bacterial metabolites. This Zenodo archive belongs to the following publication (DOI: 10.1126/science.adf5300): Klapper, M., Hübner, A., Ibrahim A. et al. Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic. Science 380, 619–624 (2023). This Zenodo archive contains the GitHub repository Paleobiotechnology/EMN001_Paleofuran with all code and and data used for the publication mentioned above, as well as additional figures, huge NMR and GCMS data, which are not stored in the GitHub repository but have been deposited in this long-term Zenodo archive (see directory tree below). All datasets and scripts required for the project analysis can be found in this directory: ├── GCMS.tar.gz├── github.tar.gz├── licenses.tar.gz├── MS_figures.tar.gz└── NMR.tar.gz

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Keywords

aDNA, metagenome binning, metagenomics, natural products, dental calculus, genome reconstruction, paleofuran, paleolithic, paleobiology, biosynthetic gene clusters, BGCs, genome assembly, chlorobium, ancient DNA, paleobiotechnology, biotechnology, heterologous gene expression

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