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ABSTRACT Structural modification of various N-substituted phthalimides compounds through such simple, rapid and environment-friendly approach polymer support method has been taken to study the bioassay and their structure-activity relationships (SAR). Derivatization of phthalimide and N-hydroxy phthalimide exhibits good antibacterial efficacy and very less antifungal potency even though parent phthalimide moiety oriented compounds are potent fungicides. Key words: N-alkyl, N-acyl, N-alkyloxy, N-acyloxy, phthalimide, antibacterial, polymer support, etc. REFERENCES Gruzdyes G. S., Zinchenko V. A. and Slovtsov R. I., 1983. The Chemical Protection of Plants, by Gruzdyes G. S., Mir Publishers, Moscow, p. 272 Nene Y. L. and Thapliyal P. N., 1993. Fungicides in plant Diease Controll, 3rd Ed., Oxford and IBH Publishing Co. Pvt. Ltd., New Delhi, p. 170. Sree Ramulu U. S., 1995. Chemistry of Insecticides and Fungicides, 2ed Ed., Oxford and IBH Publishing Co. Pvt. Ltd., New Delhi, p. 246. (a) Ullmann's: Encyclopedia of Industrial Chemistry, Editors, B. Elvers, S. Hawkins, G. Sehulz, 1991. 5th Ed., Vol. A 20, 190-191, (b) Beilstein, Handbook of Organic Chemistry, 1953. E II, 21, 348, Ames D. E. and Grey T. F., 1955. J. Chem. Soc., 3518. Cohn L., 1980. Ann., 205, 295. Greene T. W., Wuts P. G. M., 1991. Protective Groups In Organic Synthesis, 2nd Ed., Wiley: New York. Bondanszky M., Bondanszky A., 1994. The Practice of Peptide Synthesis, 2nd Ed., Springer: Heidelberg. Kocienski P. J., 1994. Protective Groups, Thieme: Stuttagart. (a) Kamiya T., Hashimoto M., Nakaguchi O., Oku T., 1979. Tetrahedron, 35, 323, (b) Townsend C. A., Nguyen L. T., 1982. Tet. Lett., 25, 4859. Breuer E., Safadi M., Chorev M., Gibson D., 1991. Phosphorus, Sulfur, Silicon, 60, 239. Nefkens G. H. L., Tesser G. I., Nivard R. J. F., 1960. Rec. In Chem., 79, 688. Kehler J. and Breuer E., 1998. Synthesis, 1419. Hajipour A. R., Mallakpour S. E. and Imanzadeh G., 2001. Ind. J. Chem., 40B, 250. Bogdal D., Pielichowski J. and Boron A., 1996. Synlett, 873. Tundo P., 1977. J. Chem . Soc., Chem. Comm., 641. Rougny par A. and Daudon M., 1976. Bull. Soc. Chim. Fr, 5-6, 833. Grochowski E. and Jupczak J., 1976. Synthesis, 683. Grochowski E. and Jupczak J., 1977. Synthesis, 277. Miitusunobu O., 1981. Synthesis, 1. Pawar N. S., Attarde S.B., Dalal D.S., Sonar G. R., Kapadi U. R., Hundiwale D. G. and Kumbhar P. P., 2001. J. Ind. Coun. Chem., 18(2), 29. Pawar N. S., Kapadi U. R., Hundiwale D. G. and Kumbhar P. P., 2002. J. Sci Ind. Res, 61, 454. Chapman and Hall, Dictionary of Organic Compound, 1982 and 1997. 5th and 6th Ed., London. Vogel A. I., 1994. Text Book of Practical Organic Chemistry, 5th Ed., ELBS and Longman, London. Pawar N. S., Dalal D. S., Shimpi S. R. and Mahulikar P. P., 2004. Euro. J. Pharma. Sci., 21, 115. Pawar N. S., Patil P. B., Suryawanshi K. C., Chaudhary S. R. and Patil J. U., 2010. J. Asia. Nat. Pro. Res., 12(2), 129.
N-alkyl, N-acyl, N-alkyloxy, N-acyloxy, phthalimide, antibacterial, polymer support, etc
N-alkyl, N-acyl, N-alkyloxy, N-acyloxy, phthalimide, antibacterial, polymer support, etc
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