In the context of the EU-funded project DIONE (No. 870378), targeted drone flight campaigns were conducted in determined Areas of Interest (AOIs) in the Lithuanian territory as a complementary source of information to the spaceborne Earth Observation (EO) open-accessed data. Such an activity attempted to overcome the limited capabilities of EO coarse resolution data to identify small-scale features alongside the agricultural fields, such as the non-productive Ecological Focus Areas (EFAs) and overall to enhance the quality and accuracy (1m or less) of the estimated Land Cover/Land Use elements. The dataset is in fact a collection of drone orthomosaic images delivered in GeoTIFF data format, which were acquired from the drone flight missions over the second AOI located near the capital of Lithuania, (Vilnius). For each area, four flight campaigns were scheduled and conducted on the following dates: 1st flight: 24-27/5/2021 2nd flight: 26-29/7/2021 3rd flight: 13-16/9/2021 4th flight: 25-28/8/2022