Siddhars found a foremost tradional system of medicine called siddha system of medicine. According to this system diseases are recognized based on vatha,pitha and kapha.The medicines are prepared using the ingredients of three main categories of natural origin. They are thavaram [herbs],thathu [metals and minerals]and jeevam [animals].Shenbaga poo kuligai is a classical siddha drug used for treating Mantham. Mantham is a paediatric illness. Suzhi Mantham is one the type of mantham under 21 types. Suzhi Mantham is a respiratory disease followed by indigestion having symptoms of intermittent fever, cough, wheezing, difficulty in breathing, rib retraction, loss of appetite and sleeplessness. Shenbagapoo kuligai a trail drug used for treating suzhi mantham, so the author have done antihistamine study for the shenbaga poo kuligai .From this study the test drug antagonise the effect of histamine when added together.